Clemson vs. Louisville odds, line: 2021 college football picks, Week 10 predictions from proven computer model

The Louisville Cardinals and the Clemson Tigers will face off in an ACC clash at 7:30 p.m. ET on Saturday, Nov. 6 at Cardinal Stadium. The Cardinals are 4-4 overall and 3-1 at home, while Clemson is 5-3 overall and 1-2 on the road. Clemson is a perfect 6-0 all-time against Louisville. 

Clemson is favored by 3.5 points in the latest Louisville vs. Clemson odds from Caesars Sportsbook, and the over-under is set at 45.5. Before making any Clemson vs. Louisville picks, you need to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. Clemson and just revealed its Week 10 college football picks and predictions. You can head to SportsLine now to see the model’s CFB picks. Here are several college football odds and betting lines for Louisville vs. Clemson:

Louisville vs. Clemson spread: Louisville +3.5Louisville vs. Clemson over-under: 46 points

Featured Game | Louisville Cardinals vs. Clemson Tigers


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