Ohio State vs. Michigan State odds, line: 2021 college football picks, Week 12 predictions from proven model

The No. 4 Ohio State Buckeyes and seventh-ranked Michigan State Spartans both have College Football Playoff aspirations, and they’ll battle Saturday to remain in the hunt. The host Buckeyes (9-1, 7-1) have won five straight against their Big Ten rivals, and they come in on an eight-game win streak and boast the nation’s top offense. Michigan State (9-1, 6-1) is still recovering from its loss to Purdue and is hoping to find the form that led to a huge victory against Michigan three weeks ago. The Spartans rebounded from their loss to beat Maryland 40-21 last Saturday, while the Buckeyes crushed Purdue 59-31.

Kickoff from Ohio Stadium is set for noon ET. The Buckeyes are the 19-point favorites in the latest Michigan State vs. Ohio State odds from Caesars Sportsbook, and the over-under for total points is set at 69.5. Before making any Ohio State vs. Michigan State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has locked in on Ohio State vs. Michigan State and just revealed its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Here are the CFB odds and betting lines for Michigan State vs. Ohio State:  

Ohio St. vs. Michigan St. spread: Buckeyes -19 Ohio St. vs. Michigan St. over-under: 69.5 points Ohio St. vs. Michigan St……

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