2021 Cheez-It Bowl prediction, odds, spread, line: Clemson vs. Iowa State picks from model on 43-30 run

The 19th-ranked Clemson Tigers will look to close their season on a six-game winning streak when they take on the Iowa State Cyclones in the 2021 Cheez-It Bowl on Wednesday afternoon. The Tigers (9-3), who will attempt to even their all-time record against schools currently in the Big 12 Conference at 7-7, will also look to improve to 26-22 all-time in bowl games. The Cyclones (7-5), who will play in their 17th bowl game in school history, look to improve on their 5-11 bowl record and even their Cheez-It Bowl mark to 1-1. The Cyclones lost to Notre Dame 33-9 in 2019, when the bowl was called the Camping World Bowl.

Kickoff from Camping World Stadium is set for 5:45 p.m. ET. The Tigers are 2.5-point favorites in the latest Clemson vs. Iowa State odds from Caesars Sportsbook, while the over-under for total points scored is set at 44.5. Before making any Iowa State vs. Clemson picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also enters the third week of the 2021-22 college football bowl season on a 43-30 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Iowa State, and just locked in its picks and Cheez-It Bowl 2021 predictions. You can visit SportsLine now to see the model’s picks. Here are several college football odds and betting lines for Iowa State vs. Clemson:

Clemson vs. Iowa State spread:…..

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