College football odds, lines, predictions for Championship Week, 2021: Model picks Cincinnati, Oklahoma State

There will be four games during the Championship Week college football schedule that have direct implications when it comes to the College Football Playoff field. No. 5 Oklahoma State will get things started when it faces No. 9 Baylor in the Big 12 title game at noon ET on Saturday. The Cowboys are 5.5-point favorites in the latest Championship Week college football odds at Caesars Sportsbook. They were able to keep their playoff hopes alive with a win over Oklahoma last week.

Other meaningful games on Saturday include championship bouts in the SEC, AAC and Big Ten. Cincinnati is a 10.5-point favorite over Houston in a game that could decide the fourth and final playoff spot. Before making any college football picks for Championship Week on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Championship Week college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Championship Week

One of the top college football picks the model is recommending for Championship Week: No. 4 Cincinnati (-10.5) covers against No. 21 Houston in the AAC Championship Game at 4 p.m. ET on Saturday. Cincinnati is one win away from…

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